Flavonoids intake about 20 mg/day decreased risk of lung cancer by10% (Tang et al., 2009; Palmioli et al., 2017) Chlorogenic acid (CGA), an important biochemical active in of polyphenol found in coffee, affects inhibition of COX-2, MMP-2, and MMP-9 expression, which eventually reduced the risk of tumor enlargement and metastasis (Bułdak et al., 2018). This evidence concerns the gene MMP2 and neoplasm.