Equivocal (2+ score) and positive (3+ score) CRC specimens showed cytoplasmic expression in 2/6 cases (33.3%) while the remaining 4/6 cases (66.7%) showed cytoplasmic/membranous expression, however, no significant relation between pattern of HER2 expression and each of subtypes, grade and stage of CRCs (Tables 2 and 3). This evidence concerns the gene ERBB2 and colorectal carcinoma.