DKC1 and cancer: Sieron et al. did not observe increased gene copy numbers in PrCa with DKC1 overexpression, so they concluded that it likely has an epigenetic role. In this respect, it could be significant that DKC1 was recently identified as a direct target of MYC by Alawi and Lee (2007), a major regulator of cancer cell growth frequently overexpressed in aggressive breast and PrCa.