Exon2 is one of the most common mutation sites in BRCA1 gene for c.68-69delAG (BIC: 185delAG) frameshift mutation which occurs in codon 23 of exon2, that results in the creation of stop codon which leads to premature termination of translation and significant truncation of protein, and is associated with the severity of the disease like early onset, bilaterality of breast cancer (Hartwig et al., 2013; Chakraborty et al., 2015). This evidence concerns the gene BRCA1 and breast cancer.