Moreover, cell viability was greatly reduced in the three BC cell lines in the combined treated group; however, in the SKBR-3 cell line, viability in the siRNA-transfected group showed a major increase, which may be due to the up-regulatory effect of HER2/neu on telomerase expression, as reported by Goueli et al., (2004) and Papanikolaou et al., (2009), who stated that hTERT expression was increased in HER2/neu positive compared with HER2/neu negative BC cell lines, where it is responsible for various biological processes, including proliferation, migration, differentiation, and apoptosis. Here, ERBB2 is linked to breast cancer.