The literature shows an association between increased uric acid and reduced synthesis of E-cadherin and induction of the epithelial-mesenchymal transition (EMT) process during the progression of renal tubular cancer (Ryu et al., 2013); therefore, increasing uric acid by inducing the differentiation of immunosuppressive IDO+/IL10+ lymphocytes can reduce tumor surveillance (Eisenbacher et al., 2014). The gene discussed is IDO1; the disease is neoplasm.