Seven genes associated with CdLS have been identified, namely, nipped‐B‐like protein (NIPBL), structural maintenance of chromosomes 1A (SMC1A) and 3 (SMC3), double‐strand break repair protein rad21 homolog (RAD21), bromodomain‐containing protein 4 (BRD4), histone deacetylase 8 (HDCA8), and ankyrin repeat Domain 11 (ANKRD11). The gene discussed is SMC1A; the disease is Cornelia de Lange syndrome.