Similar observations were found in a xenograft model of A549 lung adenocarcinoma in immunocompromised mice, wherein immunofluorescent staining revealed an abundant population of tissue‐resident Mφ (CD206‐ and/or CD301a‐positive) expressing VSIG4 within the normal stroma on the tumor periphery (Figure 3c,d). Here, VSIG4 is linked to lung adenocarcinoma.