Until recently, more than two hundreds of mutations have been identified, included nonsense mutation, missense mutation, deletion or insertion of exons in the PRKN gene that related to PD (Kitada et al., 1998; Oczkowska, Kozubski, Lianeri, & Dorszewska, 2013; Youn et al., 2019). This evidence concerns the gene PRKN and Parkinson disease.