Examples of the former are the hereditary spastic paraplegia 13 (SPG13) and the MitCHAP-60 disease (Pelizaeus-Merzbacher-like), in which the Hsp60 functions are impaired (Bross and Fernandez-Guerra 2016), and a distal sensory neuropathy associated with a mutation in the subunit 5 of CCT (Bouhouche et al. 2006a, b). Here, HSPD1 is linked to hereditary spastic paraplegia 13.