Concomitantly, targeting VISTA on T cells in mice using an agonistic anti-VISTA antibody (clone MH5A or 8G8) protects mice from graft-versus-host disease GvHD [14], hepatitis [34], lupus [7, 35], psoriasis [7] and arthritis [7]. This evidence concerns the gene VSIR and systemic lupus erythematosus.