LEF1 and colorectal cancer: Some studies reported LEF1 overexpression correlated with unfavorable prognosis in several solid tumor types, including ESCC, nasopharyngeal carcinoma (NPC), and colorectal cancer (CRC) [16–18]; while other studies found a positive relationship of LEF1 expression with favorable prognosis in blood tumors, such as AML and ALL [15,19].