Some studies reported LEF1 overexpression correlated with unfavorable prognosis in several solid tumor types, including ESCC, nasopharyngeal carcinoma (NPC), and colorectal cancer (CRC) [16–18]; while other studies found a positive relationship of LEF1 expression with favorable prognosis in blood tumors, such as AML and ALL [15,19]. The gene discussed is LEF1; the disease is esophageal squamous cell carcinoma.