Due to the obvious heterogeneity among these studies (I2 = 80.6%, P=0.000), a random-effects model was used and a significant relationship was observed between elevated LEF1 expression and poor OS of cancer patients (HR = 1.74, 95% CI: 1.06–2.86, P=0.029) (Figure 2A). This evidence concerns the gene LEF1 and cancer.