More importantly, predominant Th1 and Th17 responses present as colitis-related abundant CD4+ IFN-γ+ Th1 and CD4+ IL17+ Th17 cells that infiltrate into the colon mucosa LP, and colitis-mediated upregulated IFN-γ and IL-17A mRNA transcripts in the intestinal tissues were found in colitis mice. This evidence concerns the gene CD4 and colitis.