CD40LG and metastatic melanoma: In our study, the host's ability to generate an early antiganglioside response is supported by a significantly increased titter of IgM antibodies in patients with primary versus metastatic melanoma and the control group, for anti-GM1, anti-GM2, anti-GM3, anti-GD1a, anti-GD1b, anti-GT1b, and anti-GQ1b (Figure 2).