The presence of IgG and IgM antiganglioside antibodies in primary melanoma was (%), as follows: antiGM1 (5.0 and 13.1), antiGM2 (1.8 and 18.1), antiGM3 (0.6 and 5.6), antiGD1a (0.6 and 15.0), antiGD1b (3.7 and 10.7), antiGT1b (0.0 and 13.1), antiGQ1b (0.0 and 5.0). This evidence concerns the gene CD40LG and melanoma.