Among them, the PI3K/Akt, Ras/MEK/ERK, and MAPK signaling pathways were involved in the prevention and treatment of intervertebral disc degeneration by sIL-13Rα2-Fc; among these three, pathways involved in cancer (2 genes) contained the most abundant genes. This evidence concerns the gene AKT1 and Intervertebral disk degeneration.