In addition, the comprehensive GO annotation and KEGG pathway analyses of differentially expressed genes revealed that Adamts8 is involved in the extracellular matrix signaling pathway, and thus, we further speculate that Adamts8 may play a role in the process by which sIL-13Rα2-Fc attenuates intervertebral disc degeneration. Here, ADAMTS8 is linked to Intervertebral disk degeneration.