Simultaneously, AS-IV may suppress NOX2 expression, together with inhibition of PANX1 expression, to reduce ROS production and ROS-related TXNIP-promoted NLRP3 activation by enhancing TRX expression, inhibiting caspase1 activation, and IL-1β and IL-18 production in the kidney of DN rats [52, 54]. Here, IL18 is linked to liver dysplastic nodule.