Liang et al. [22] showed that IL-6 and integrin β6 expression could be used as a predictor of poor overall survival of CRC; here, we not only validate the positive relationship between the expression of IL-6 and integrin β6 besides their association with disease severity of CRC patients in another single-center study but also show for the first time that IL-6 upregulates integrin β6 expression. This evidence concerns the gene IL6 and colorectal carcinoma.