IL6 and colorectal carcinoma: In our prior study, we found that the MAPK/Ets-1 signaling pathway was also involved in the dysregulation of integrin β6 [47]; however, through pathway inhibitors, we found that ERK/MAPK and PI3K pathways were dispensable in IL-6-induced integrin β6 expression, suggesting the preferred role of the STAT-3 pathway in IL-6-mediated CRC progression.