Indeed, the three β-ARs are expressed and involved in the pathogenesis and/or progression of different tumors, from benign form such as the infantile hemangioma [27, 28] to several malignant types including breast cancer [29], ovarian cancer [30, 31], melanoma [32, 33], colon cancer [34], and many others. The gene discussed is CTBP1; the disease is melanoma.