APP and early-onset autosomal dominant Alzheimer disease: In Alzheimer's disease, BBR could be effective in decreasing the generation of the beta-amyloid (Aβ) peptide by APP processing in H4 human neuroglioma cells, and in inhibiting the activity of beta-site APP cleaving enzyme-1 (BACE-1) in a rabbit model of Alzheimer's disease [96, 97].