BECN1 and hepatocellular carcinoma: In HepG2 and MHCC97-L hepatic carcinoma cells, BBR induces autophagic cell death by the activation of Beclin-1 (BECN-1) and the inhibition of m-TOR signaling through the downregulation of Akt activity and the upregulation of P38 MAPK signaling [114].