MAP2K7 and triple-negative breast carcinoma: In triple-negative breast cancer cells, BBR suppresses cell migration by the inhibition of TGF-β1 expression by reduction of matrix metalloproteinase-2 (MMP-2) and MMP-9 expression [117] and by the downregulation of EGFR protein and by suppression of IL-8 expression due to the inhibition of MEK and ERK phosphorylation, leading to inhibition of the EGFR/MEK/ERK signaling and invasiveness [118].