IL37 and hypertensive disorder: Guo et al. have demonstrated the effect of BBR in delaying the onset, severity, and the pathophysiology of hypertension by activating the renin-angiotensin system (RAS) and proinflammatory cytokines such as IL-6, interleukin-17 (IL-17), and interleukin-23 (IL-23) in hypertensive rats [90].