COL1A2 and Familial prostate cancer: In PC-3 and DU145 prostate cancer cells, BBR downregulates the expression of genes involved in the epithelial-mesenchymal transition (EMT), including platelet-derived growth factor receptor beta (PDGFR), bone morphogenetic protein 7 (BMP7), and collagen type I alpha 2 (COL1A2), and represses the expression of the EMT transcription factor Snail-1, with inhibition of the migratory and invasive capability of these cancer cells [119].