NOS3 and type 2 diabetes mellitus: Indeed, BBR reduces reactive oxygen species (ROS) production, enhances the phosphorylation and activation of the endothelial nitric oxide synthase (eNOS) due to activation of AMPK, and downregulates the expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) 4 in a dose-dependent manner, leading to improved endothelial function in type 2 diabetes [80–82].