In addition, Wen et al. have reported that the combination of BBR and tamoxifen (TAM) induced cell cycle arrest in the G1 phase and apoptosis through the induction of p21Cip-1 and the increase of the Bax/Bcl-2 ratio in MCF7 and tamoxifen-resistant MCF7/TAMR breast cancer cells [112]. Here, BCL2 is linked to breast cancer.