Graham et al. have demonstrated that the combined treatment with RV and 2-Deoxy-D-glucose (2-DG) induced the activation of caspase-3 protein and apoptotic cell death, compared to 2-DG treatment alone in NB1691RV NB cells, and decreased 2DG-induced phosphorylation and activation of Akt at T308, T450, and S473, potentiating endoplasmic reticulum (ER) stress, in NB1691, SH-SY5Y, SK-N-SH, and SK-N-BE2 cells [62]. The gene discussed is CASP3; the disease is neuroblastoma.