AKT1 and hepatocellular carcinoma: Li et al. have demonstrated that the effect of BBR on the suppression of the cell cycle in the G0/G1 phase in HCC hepatocellular carcinoma cells occurred through the enhanced expression of CDKIs p21Cip1 and p27Kip1 via Akt/FocO3a/Skp2 axis regulation [107].