Furthermore, myeloid monocytic cells such as myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), and dendritic cells are recruited to the tumor site mainly by CCL2 and produce many proangiogenic factors such as VEGF, CXCL8, platelet-derived growth factor (PDGF), and transforming growth factor beta (TGF beta) [118–120]. Here, CCL2 is linked to neoplasm.