Interestingly, in numerous tissues, the activation of PPAR gamma inhibits the beta-catenin pathway, whereas the stimulation of the canonical Wnt/beta-catenin signal cascade also inactivates PPAR gamma [45], implicating a negative regulatory role of PPAR gamma in carcinogenesis where tumor angiogenesis might be a fundamental step. This evidence concerns the gene CTNNB1 and neoplasm.