In myeloma, methylation-mediated silencing of BM742401 is tumor-specific, reversible, associated with inferior OS, and likely an early event in myelomagenesis, and BM742401 is a tumor suppressor lncRNA by inhibiting myeloma cell migration, hence implicated in myeloma plasma cell homing and metastasis. The gene discussed is GATA6-AS1; the disease is plasma cell myeloma.