CXCL12 and neoplasm: Herein, we confirmed BM742401 as a tumor suppressor in myeloma, as evidenced by the inhibition of myeloma cell migration in myeloma cells with stable overexpression of BM742401. In myelomagenesis, there is constant trafficking of myeloma cells through the blood to the bone marrow niches, a process termed homing, due to secretion of SDF-1 by BMSC, thereby creating a concentration gradient from the BM stroma to the circulating plasma cells [47].