Further analysis determined that the DNA-demethylating agent 5-azadC induces BC cell autophagy, as indicated by increased levels of the autophagy marker LC3B-II (Fig. 4c), and that blockade of autophagy with bafilomycin A is sufficient to rescue 5-azadC-induced ERRα degradation (Fig. 4d). The gene discussed is ESRRA; the disease is breast cancer.