To verify whether ERRα regulation of DNA methylating enzyme expression is subtype-specific, we looked at protein levels of DNMT1 after knockdown of ERRα by RNA interference in MCF7 cells, an ER+ BC cell line, as well as in the three TNBC cell lines MDA-MB-231, MDA-MB-436, and MDA-MB-468. Here, DNMT1 is linked to breast cancer.