In contrast, mRNA expression of enzymes involved in the biosynthesis of glycosphingolipids, including glucosylceramide synthase (UCGC), and lactosylceramide synthases B4GALT5 and B4GALT6, were elevated in CAV1-high prostate cancer cell lines and prostate tumors (Fig. 3a, b). This evidence concerns the gene B4GALT6 and Familial prostate cancer.