CAV1 and neoplasm: Key features of this tumor supportive metabolic program include Cav-1 mediated lipid uptake, increased tumor catabolism of extracellular sphingomyelins, and altered ceramide metabolism coupled with increased glycosphingolipid synthesis and efflux of circulating Cav-1-sphingolipid particles that comprise cargoes indicative of intersection with mitochondrial remodeling.