M6PR and cervical carcinoma: As loss of M6PR has been associated with disrupted endolysosomal transport of hydrolases, decreased lysosome function, and impaired autophagy in cervical cancer cells54, we tested in CMT93 cells and found knockdown of M6PR (M6prKD) indeed cause reduced activity of lysosomal hydrolases and impaired cargo degradation (Fig. 4f, g, Supplementary Fig. 5d), which were also found in Gal-9−/− cells.