LGALS9 and colorectal carcinoma: Similar to mouse tissues, Gal-9 is also abundantly expressed in colon crypts in healthy human tissues but significantly lower in patients with colorectal cancer (CRC), inflammation (IBD), ulcerative colitis (UC), and CD (Supplementary Fig. 1d, e), especially in CD patients which might suggest why Gal-9 is a risk factor25.