CD274 and non-small cell lung carcinoma: There is growing evidence that cytotoxic chemotherapy alters the immunosuppressive tumor microenvironment and activates immune response to kill tumor cells.11 Thus, in this study, a classical cytotoxic chemotherapeutic drug MMC was shown to upregulate PD-L1 and MHC-I expressions and enhanced the antitumor immune response in NSCLC cells.