CD274 and non-small cell lung carcinoma: The transcription factor NF-κB is an important mediator of cellular responses to inflammatory stimuli.32,33 To this end, NF-κB p65 has been reported to regulate MHC-I and PD-L1 expression transcriptionally.25 The effect of MMC on the expression of p65 sub-unit of NF-κB in NSCLC cells after 48 h treatment of MMC was evaluated.