Using a complex of new analytical paradigms that integrates transcriptomes and methylomes of normal controls, AD patients, and “AD-in-dish” models, we identified a set of previously unexplored FUS-specific AD genes (COL2A1, CAPN3, COL14A1, STAT5A, and SPOCK3) and their epigenetic characteristics, which may provide new insights into the molecular pathology of AD. The gene discussed is CAPN3; the disease is Alzheimer disease.