Bouchama et al. [38] prospectively analysed the blood specimens of 22 HS patients at admission and found that the levels of endothelin, von Willebrand factor (vWF) and intercellular adhesion molecule-1 (ICAM-1) were significantly increased, suggesting that vascular endothelial cells were significantly impaired in patients at the early stage of HS pathogenesis. Here, ICAM1 is linked to histiocytic sarcoma.