The NLRP3 have been shown to contribute to immune responses to infection with Trypanosoma cruzi [22], Toxoplasma gondii [23], Paracoccidioides brasiliensis [24], and Leishmania species [25], whereas the role of NLRP3 in the immune response to Trichinella spiralis infection is not yet clear. Here, NLRP3 is linked to infection.