The Th2 response with upregulation of IL-4 induced by T. spiralis promotes the development of eosinophils, mastocytosis, mast cell degranulation, and an immunoglobulin E (IgE) response that is associated with protection against T. spiralis infection [3].Treg response was involved in the anti-inflammatory effects of helminth infection and exist in the ML phase [42]. Here, IGHE is linked to helminthiasis.