ERBB2 and breast neoplasm: Chen, et al. generated anti-HER2 scFv containing the azide group for conjugating with the amine group of Cy5-dots to form anti-HER2 Cy5-dots, and the tumor uptake of anti-HER2 Cy5-dots had a 2.4 fold increase compared with untargeted dots in BT474 breast tumor-bearing mice [23].