To investigate whether mPEG × HER2 can enhance tumor accumulation of PEGylated liposomal DiR (Lipo-DiR) in HER2 over-expressing tumors, we first mixed mPEG × HER2 and mPEG × DNS with Lipo-DiR to form αHER2/Lipo-DiR and αDNS/Lipo-DiR. This evidence concerns the gene ERBB2 and neoplasm.