Liu et al. depicted a more complicate scenario, in which they found that about 70% of endometrial tumors exhibit m6A hypomethylation, probably due to a hotspot mutation in METTL14 or reduced expression of METTL3, which resulted in downregulation of the negative AKT regulator PHLPP2 and upregulation of the positive AKT regulator mTORC2 [117]. The gene discussed is AKT1; the disease is endometrium neoplasm.