METTL3 and neoplasm: Other mRNA transcripts, including AFF4, IKBKB, RELA, and MYC, were revealed to be targets of METTL3 and mediated the role of METTL3 in promoting cell proliferation, invasion, and survival [85], whereas SETD7 and KLF4 tumor suppressors were negatively regulated by METTL3 in a YTHDF2-dependent manner [88].