Chen et al. also found that intravenous (i.v.)injection of liposomal nanoparticle-delivered cGAMP (cGAMP-NP) could activate the STING axis more effectively than soluble cGAMP and converted the immunosuppressive TME to a tumoricidal state in a transplanted B16F10 cell melanoma model and in a genetically engineered triple-negative breast cancer model [115]. Here, STING1 is linked to melanoma.