HMGB1 and familial pancreatic carcinoma: Pancreatic cancer is one of a malignant disease that resists to some of the available chemotherapies, as the battle continues to eliminate this burden, the researchers found that exosomes may be excellent tools to prevent this problem, for example, it has been reported that microRNA-410-3p significantly reduced the PC cancer resistance to gemcitabine by inhibiting HMGB1-mediated autophagy this made the exosomes to be considered as good candidates to be used in treating pancreatic cancer [82].