TGF-β and MIF, CCL2, CXCL5, CXCL8 and CXCL12 seem might represent the fulcrum of an autocrine/paracrine system able to: i) promote repair of damaged DNA and increase cell proliferation; ii) induce angiogenesis and enhance metastatic potential; iii) protect tumor cells from RT-induced ICD; iv) promoting stemness. The gene discussed is CXCL5; the disease is neoplasm.