Additionally, JK Park et.al showed that the ICAM3 can enhance the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt pathway [45] showed that the ICAM3 can enhance the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt pathway. This evidence concerns the gene MMP2 and non-small cell lung carcinoma.