The top pathways significantly regulated in this group comparison were amyotrophic lateral sclerosis signaling implicating an upregulation in oxidative stress, changes in gluconeogenesis and glycolysis pathways indicating an impairment in mitochondrial bioenergetics, and phosphodiesterase type 5 (PDE5) inhibition which implicates a deficiency in the vasodilatory effect of smooth muscle cells of the highly vascularized stroma that could impact on vascular permeability, inflammation and vascular leakage. The gene discussed is PDE5A; the disease is amyotrophic lateral sclerosis.