CLDN5 and Alzheimer disease: Another recent study utilizing the Brown-Merck Gene Expression Omnibus database (CP transcripts) to interrogate genes in AD vs control choroid plexus tissue also revealed changes in ion transporters (e.g. solute carrier SLC4A5) and related enzymes (e.g. carbonic anhydrase CA4), decreased expression of tight junction protein, claudin-5 involved and mitochondrial ATP synthesis (e.g. adenosine triphosphate ATP5L), increased expression of pro-inflammatory mediator, interleukin 1 receptor like 1 (IL1RL1) and amyloid precursor protein (APBA3), [39].