Remodeling of the epithelial adherens junctions, Fc γ receptor mediated phagocytosis in macrophages and monocytes and RhoA signaling were among the top pathways observed to ‘specifically’ correlate with amyloid score, and could be involved in driving the pathogenesis of amyloidosis or alternatively be a consequence of significant ß-amyloid pathology. The gene discussed is RHOA; the disease is amyloidosis.