IPA analyses identified molecular pathways significantly altered between these two groups, consisting of changes in aspects of amyotrophic lateral sclerosis signaling, superoxide radical degradation, tricarboxylic acid cycle (TCA) cycle and disruptions in several energy metabolic pathways, remodeling of the epithelial adherens junctions, Fc γ receptor mediated phagocytosis in macrophages and monocytes, and RhoA signaling which is implicated in cytoskeletal dynamics, transcription, cell cycle maintenance and cell development. The gene discussed is RHOA; the disease is amyotrophic lateral sclerosis.