ESR2 and type 2 diabetes mellitus: This report indicated that the recessive model of ESR2 rs1256031 gene polymorphism was correlated with a reduction of ocular disease risk, which has been also reported as a protective factor in developing type 2 diabetes mellitus.28 Mice lacking ERβ are more susceptible to in vivo injury to RPE cells29, which supports a protective effect of ERβ.