This report indicated that the recessive model of ESR2 rs1256031 gene polymorphism was correlated with a reduction of ocular disease risk, which has been also reported as a protective factor in developing type 2 diabetes mellitus.28 Mice lacking ERβ are more susceptible to in vivo injury to RPE cells29, which supports a protective effect of ERβ. Here, ESR2 is linked to diabetes mellitus.