The mutational screening showed that 52 (37.4%) out of 139 genetically tested BBC patients harbored germline PVs (class V) in several high- and intermediate-penetrance BC susceptibility genes including BRCA1 and BRCA2, one patient showed a heterozygous PV in MUTYH gene, 27 (19.4%) patients were carriers of variants of uncertain significance (VUS; class III), six of which in BRCA1/2, whereas 59 (42.5%) showed no genetic variants (classes III, IV, and V) (Table 1). This evidence concerns the gene BRCA1 and breast cancer.