Some patients with negative test result for BRCA1/2 PVs may harbor a still undiscovered PV in these genes, probably due to the sequencing limitations, or PVs in other cancer susceptibility genes, including ATM, CHEK2, PALB2, PTEN, TP53, and others, in 3–4% of cases [34,35]. This evidence concerns the gene TP53 and cancer.