STAT3 and cancer: The transfer process of FFA between adipocytes and cancer cells is mediated by fatty acid-binding protein 4 (FABP4), which supplies energy to the cells and also active oncogenic pathways like IL-6/STAT3/ALDH1, leading to an enhanced stem cell-like phenotype and tumor progression [133]; FABP4 expression increased in cancer cells co-cultivated with adipocytes [155].