In 2014, Zanotti et al. [34] further managed to inactivate NOTCH signaling by crossing homozygotic mice with mice where the promoter osterix governs the expression of Cre, while in 2018 [35], they presented their mouse model of HCS (NOTCH2tm1.1Ecan) to study the link between the disease and osteoarthritis. The gene discussed is SP7; the disease is osteoarthritis.