It has been described that diminished HGF and EGF secretion by diseased lacrimal tissue in keratoconjunctivitis sicca could have a role in the pathophysiology of the disease and that the levels of EGF, HGF, and KGF mRNAs increase in lacrimal gland tissue in response to corneal epithelial wounding [57,81], pointing to a common function for them. This evidence concerns the gene EGF and Keratoconjunctivitis sicca.