EIF2A and amyotrophic lateral sclerosis: In mouse models, Sephin1, a derivative of guanabenz, was shown to inhibit eIF2α dephosphorylation via the inhibition of GADD34, as well as inhibit the global protein translation recovery, prevent stress-induced damage in cells and delay PMD development, such as Charcot-Marie-Tooth 1B, in ALS mice models [181].