Different UPR markers such as p-IRE1, active ATF6α, p-PERK and p-eIF2α, BiP and CHOP were found in patients with neurodegenerative diseases including Alzheimer’s [26], Parkinson’s [27,28], Amyloid lateral sclerosis (ALS) [29], prion diseases [30] among others [31]. The gene discussed is EIF2AK3; the disease is prion disease.