Many genes have been identified as ALS disease-causative, such as protein disulfide isomerase (PDI) and the superoxide dismutase1 (SOD1), TAR DNA-binding protein (TARDBP or TDP-43), fused in sarcoma (FUS/TLS), chromosome 9 open reading frame 72 (C9ORF72), vesicle-associated protein-associated protein B (VAPB) and Sigma-1 receptor (SIGR1) among others [24,111]. This evidence concerns the gene P4HB and amyotrophic lateral sclerosis.