Interestingly, a recent study by Min et al. [97] used a high-fat diet-fed apolipoprotein E knock-out (ApoE--KO) mice model of atherosclerosis to demonstrate that microRNA-26a overexpression, through TRPC3 inhibition, suppressed inflammatory responses and the NF-κB pathway, promoting cell viability and inhibiting apoptosis in oxidized low-density lipoprotein (ox-LDL)-stimulated ECs. The gene discussed is APOE; the disease is atherosclerosis.