In summary, PAH is associated with the upregulation of TRPC1/C3/C4/C6 and TRPV1/V3/V4 (Table 1), which play an important role in the increase of Ca2+ influx in PASMCs and in their proliferation and migration, which are critical steps for pulmonary artery remodeling. The gene discussed is TRPV1; the disease is pulmonary arterial hypertension.