The same approach was employed by Selvaraj et al. [93] to correct limb-girdle muscular dystrophy type 2A (LGMD2A) patient-derived iPSCs, demonstrating the rescue of the CALPAIN 3 gene in both in vitro and in a mouse model. Here, CAPN3 is linked to autosomal recessive limb-girdle muscular dystrophy type 2A.