GH1 and Prader-Willi syndrome: Moreover, its clinical value is potentially disadvantaged by several disorders affecting these patients with PWS, such as (1) abnormalities in muscle development, tone, strength, structure, ultrastructure; (2) intrinsic defects of neuro-sensitive and neuro-motor functions; (3) the multifactorial origin of short stature; (4) interindividual inhomogeneity for past/current exposure to GH [1,2,3,4,6,8,9,10,51,52].