Enhanced tubular reabsorption of salt is important in the pathogenesis of obesity-related hypertension by regulating phosphorylation of Na+-K+-2Cl− cotransporter and regulation of STE20/SPS1-related proline/alanine-rich kinase (SPAK)/oxidative-stress-responsive kinase-1 (OSR1) by AMP-activated protein kinase [26]. The gene discussed is SLC12A1; the disease is obesity due to melanocortin 4 receptor deficiency.