Although MYL2-CUX2 rs12229654 and its association with hypertension were first reported in this study, a strong association of genetic variants of MYL2-CUX2 with high-density lipoprotein cholesterol was shown in a Korean GWAS meta-analysis, and it was replicated in a BioBank Japan GWAS, Health 2, and Shanghai Jiao Tong University cohort [51]. Here, CUX2 is linked to hypertensive disorder.