Chromosome 6 open reading frame 10(C6orf10), human leukocyte antigen (HLA)-DQB1, ring finger protein (RNF)213, glycosylphosphatidylinositol anchored molecule-like (GML), cytochrome P450 family 11 subfamily B Member 1(CYP11B1), myosin light chain 2 (MYL2), cut like homeobox 2 (CUX2), and jagged1(JAG1) were significantly associated with hypertension in participants whose sodium intake was greater than 2 g/day, while loci in echinoderm microtubule-associated protein-like 6 (EML6) were significantly associated with hypertension in participants whose sodium intake was less than 2 g/day. This evidence concerns the gene CYP11B1 and Hypertension.