Susceptibility of Boxers and French bulldogs to E. coli-associated GC is linked to a region encoding the CD48/SLAM family of genes on Canis Familiaris (CFA) chromosome 38, which is implicated in human IBD and the selective sensing and killing of E. coli by murine macrophages [3,17,18,19,20]. The gene discussed is CD48; the disease is irritable bowel syndrome.