MYC and neoplasm: In 2013, Conde et al. conjugated RGD peptide and thiolated siRNA to PEG-modified Au NPs, making it possible to deliver siRNA to tumor cells and effectively silence target oncogenes, then down-regulate c-Myc oncogene and inhibit tumor growth, as well as prolong the survival time of mice with lung cancer [87] (Figure 8B).