CDH1 and colon carcinoma: We found that 1,25(OH)2D3 upregulates the KDM6B gene by activating its promoter, and that KDM6B knockdown reduces the induction of E-cadherin and cell differentiation and the inhibition of β-catenin transcriptional activity promoted by 1,25(OH)2D3 in colon carcinoma cells [50].