These findings are clinically relevant, as they indicate that colon cancer patients may benefit from an adequate vitamin D status or from treatment with VDR agonists, provided their CAFs express VDR, even though their carcinoma cells may be VDR-deficient, for instance due to SNAIL1 and/or SNAIL2 upregulation. The gene discussed is VDR; the disease is malignant colon neoplasm.