Interestingly, the concomitant treatment with sildenafil produced significant effects only in SSc cells reducing the MIF secretion induced by hydrogen peroxide (50 μM H2O2 vs. 50 μM H2O2 + S: 19,685.0 ± 9135.0 vs. 4127.0 ± 1367.0, p < 0.01 and 100 μM H2O2 vs. 100 μM H2O2 + S: 47,417.0 ± 15,026.0 vs. 17,285.0 ± 6374.0, p < 0.01) (Figure 5E). This evidence concerns the gene MIF and systemic sclerosis.