There are evidences of antioxidative effects of sildenafil on different cell lines and animal models [19,20,21,26,27,54,55,56], and very recently, our group has shown that sildenafil was involved in ROS-mediated signaling through the modulation of Signal transducer and activator of transcription (STAT) 3, ERK, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-Κb), and protein kinase B (PKB/AKT), as well as in reducing the expression/secretion of proinflammatory and profibrotic cytokines in SSc fibroblasts exposed to H2O2 [23]. Here, AKT1 is linked to systemic sclerosis.