MIF and systemic sclerosis: As already demonstrated by Kim et al. (2008) [38], the analysis of the macrophage migration inhibitory factor (MIF) revealed already at the basal level profound differences, with SSc cells showing higher levels compared with the healthy control (healthy vs. SSc: 586.3 ± 5.1 vs. 2448.0 ± 30.1, p < 0.05) (Figure 5E).