SUN2 and HIV-1 infection: Moreover, lamin A/C tethered the inner nuclear membrane protein Sad1 and UNC84 domain containing 2 (SUN2) to the nucleosomes 1 and 2 promoting the repressive chromatin including the HIV-1 5′-LTR an so, repressing the initiation and elongation of HIV-1 transcription, therefore regulating HIV-1 infection and latency [140].