Aberrant swollen mitochondria morphology has also been observed in neuronal, non-neuronal cells, and muscle tissue of other fALS cases, such as SOD1 [24,89] and C9orf72 [25,89]-mutated ALS patients but, also, in both SOD1G93A and TDP-43A315T murine models [44,90,91]. Here, SOD1 is linked to amyotrophic lateral sclerosis.