FIG4 and amyotrophic lateral sclerosis: Other gene mutations associated to ALS, such as protein polyphosphoinositide 5-phosphatase (FIG4) [201,202] or spastacsin (Spg11) [203,204], are associated with the blockade of lysosomal clearance (see Section 7)—the blockade of which could potentially lead to vesicle secretion [198].