Interestingly, spinal motor neurons have been reported to display a reduced expression of GluA2 relative to dorsal horn neurons from the same region, providing some explanation for the selective susceptibiltiy of motor neurons in ALS [147], and GluA2 transcriptional editing has been found to be impaired in motor neurons of sporadic ALS patients relative to controls [148]. The gene discussed is GRIA2; the disease is amyotrophic lateral sclerosis.