SOD1 and amyotrophic lateral sclerosis: Oxidative stress results from an imbalance between the production and elimination of reactive oxygen species (ROS) [45], as well as an impaired ability to repair ROS-mediated toxicity [46], and has been of particular interest in ALS pathogenesis ([47] and Figure 1) since the discovery of SOD1 mutations in familial forms of ALS [48].