In C9orf72 knockdown cell lines [189], a C9orf72 knockout murine model [193], and in ALS patient fibroblasts and iPSC-derived motor neurons [194], transgolgi and endosomal trafficking were reduced, a defective autophagy pathway was observed [34,194], and exosomal secretion was affected [194]. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.