Most of these models investigate the pathological effects of mutations to ALS genes, including Fused in Sarcoma (FUS), Superoxide dismutase (SOD1), TAR DNA-binding protein 43 (TDP-43), and Chromosome 9 open reading frame 72 (C9orf72) [22,23]. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.